ZAVAN BARBARA

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Struttura Dipartimento di Scienze Biomediche (DSB)
Telefono 0498276096
Qualifica Professore associato confermato
Settore scientifico MED/46 - SCIENZE TECNICHE DI MEDICINA DI LABORATORIO
Rubrica di Ateneo  Visualizza
 

Aree di ricerca
Zavan Barbara, is Assistant Professor of Hystology and head of Tissue Engineering and regenerative laboratory at Biomedical Sciences Department of Padova University (Italy). Dr. Zavan received her Ph.D. in Tissue Enginering and regenerative medicine from Padova University, and completed postdoctoral training in stem cell biology at Padova University. Dr. Zavan’ research seeks to understand how changes in stem cell activity impact tissue homeostasis and repair throughout life and to identify systemic molecules or surfaced modification are responsible for regulation of regenerative potential. Her scientific activity is reppresented by several indexed pubblication books chapter mailny focused on tissue engineering and stem cells. She is a member of scientific society such as: Tissue Engineering and Regenerative Medicine International Society IS and American Nano Society American Nano Society. She is editorial board of Recent patent on nanotechnologies; The Scientific World JOURNAL (as part of the journal's Tissue Engineering Domain); Journal of Biosciences and Medicines (JBM).

Dr. Zavan research activities have focused for many years on tissue engineering by means several biomaterials as scaffold for the creation of in vitro artificial tissue such as: skin, cartilage, bone. “Smart scaffold” biomaterials are comprised of hyaluronan derivatives, namely the benzyl ester of this extracellular polysaccharide, collagene based sponge-granules, matrices etc. All these scaffolds are highly biocompatible and when placed inside the human body, do not elicit any adverse reactions and are resorbed by the host tissues.
Dr. Zavan applied a multidisciplinary approaches with the aim to improve regenerative medicine strategies for the clinical applications:
a) biomaterials as scaffolds for in vivo regeneration of:
• vessels (vein, artery)
• bone
• cartilage
• skin
• dental pulp

b) Use of adult cells and stem cell:
• human dermal fibroblasts: able to attach to the biomaterial fibers, proliferate, colonize the entire device, and secreted the main extracellular molecules (collagen type I, III and IV, laminin, fibronectin) giving rise to a dermal-like tissue;
• keratinocytes able to give rise a complete skin equivalent when they are in vitro cultured onto this dermal substitute,
• endothelial cells seeded into this in vitro reconstructed connective tissue are able to proliferate and organize themselves into microcapillary structures;
• chondrocytes were cultured inside non-woven Hyaff™ (Hyaluronic benzilic ester, FIDIA Abano Terme) scaffolds, are able to generate clusters of proliferating chondrogenic cells that produce type II collagen and proteoglycans were obtained.
• Hepatocytes and pancreatic cells
• Schwann cells: periphelar nerve reconstruction
• Adult Stem Cells from fetal tissue (amios),
• Adult Stem cells from adult tissue such as skin, bone marrow, adipose tissue, dental pulp able to differentiate to several cell line including: bone, cartilage, adipose tissue, muscle tissue, nerve.
• Use of Adult stem cells as tool for the treatment of tumor.

The in vitro reconstructed of dermal substitutes and cartilage like tissue obtained by culturing the patient own fibroblasts/chondrocytes into a 3D Hyaluronan based scaffolds, are routinely used in the clinical practice in many hospital or the treatment of skin/cartilage lesion.

facilities
The laboratory of Dott.ssa Zavan is located in the "Vallisneri Building", a large pluridepartimental complex

Pubblicazioni
Title: Assistant Professor
Telephone: 049 827-6096

E-mail: barbara.zavan@unipd.it

Career/Employment
1996 Degree in Biological Sciences, University of Padova (Italy), summa cum laude
1996-2000 Research fellowship at University of Padova, Institute of Histology, Italy for the study of in vitro reconstruciotn of skin and cartilage
2000-2004 PhD-on tissue engineering and regenerative medicine, Padova University
2004-2010 Post-doctoral fellow in Stem cell and regenerative medicine, at Hystology, Microbiology and Biomedical Technology, Padova University
2010-present Assitant Professor of Histology in the School of Medicine, University of Padova

Research interest
Zavan Barbara, is Assistant Professor of Hystology and head of Tissue Engineering and regenerative laboratory at Biomedical Sciences Department of Padova University (Italy). Dr. Zavan received her Ph.D. in Tissue Enginering and regenerative medicine from Padova University, and completed postdoctoral training in stem cell biology at Padova University. Dr. Zavan’ research seeks to understand how changes in stem cell activity impact tissue homeostasis and repair throughout life and to identify systemic molecules or surfaced modification are responsible for regulation of regenerative potential. Her scientific activity is reppresented by several indexed pubblication books chapter mailny focused on tissue engineering and stem cells. She is a member of scientific society such as: Tissue Engineering and Regenerative Medicine International Society IS and American Nano Society American Nano Society. She is editorial board of Recent patent on nanotechnologies; The Scientific World JOURNAL (as part of the journal's Tissue Engineering Domain); Journal of Biosciences and Medicines (JBM).

Dr. Zavan research activities have focused for many years on tissue engineering by means several biomaterials as scaffold for the creation of in vitro artificial tissue such as: skin, cartilage, bone. “Smart scaffold” biomaterials are comprised of hyaluronan derivatives, namely the benzyl ester of this extracellular polysaccharide, collagene based sponge-granules, matrices etc. All these scaffolds are highly biocompatible and when placed inside the human body, do not elicit any adverse reactions and are resorbed by the host tissues.
Dr. Zavan applied a multidisciplinary approaches with the aim to improve regenerative medicine strategies for the clinical applications:
a) biomaterials as scaffolds for in vivo regeneration of:
• vessels (vein, artery)
• bone
• cartilage
• skin
• dental pulp

b) Use of adult cells and stem cell:
• human dermal fibroblasts: able to attach to the biomaterial fibers, proliferate, colonize the entire device, and secreted the main extracellular molecules (collagen type I, III and IV, laminin, fibronectin) giving rise to a dermal-like tissue;
• keratinocytes able to give rise a complete skin equivalent when they are in vitro cultured onto this dermal substitute,
• endothelial cells seeded into this in vitro reconstructed connective tissue are able to proliferate and organize themselves into microcapillary structures;
• chondrocytes were cultured inside non-woven Hyaff™ (Hyaluronic benzilic ester, FIDIA Abano Terme) scaffolds, are able to generate clusters of proliferating chondrogenic cells that produce type II collagen and proteoglycans were obtained.
• Hepatocytes and pancreatic cells
• Schwann cells: periphelar ner

Insegnamenti dell'AA 2018/19
Corso Curr. Codice Insegnamento CFU Anno Periodo Responsabile
SC1177 000ZZ SCN1032629 ANATOMIA UMANA 7 I Primo semestre BARBARA ZAVAN
IF0375 000ZZ MEP3051647 ISTOLOGIA, BIOCHIMICA, PRINCIPI DI NUTRIZIONE 12 I Annuale DIEGO DE STEFANI